Despite all the information out there about how to lose weight, there are many reasons why it’s hard to do so. Genetics, environment, and complex body systems all play a role in determining how much weight you can lose. Fortunately, there are things you can do to break unhealthy routines and make your weight loss journey much easier.
Genetics
Several studies have investigated the relationship between genetics and weight loss. These studies focused on genetic variants that predispose people to obesity. The NIH Working Group on Genetics and Weight Loss discussed the importance of genetics in the fight against obesity. It also described possible research directions for the future.
There are at least 50 genes that are associated with body weight and waist circumference. These genes affect a person’s physical appearance, eating habits, and exercise tolerance. In addition, they affect the likelihood of gaining weight after dieting. In addition, some genes signal an average response to sweet tastes.
The FTO gene is involved in fat storage and food intake regulation. Researchers have found that people with the FTO gene are more likely to be obese and less likely to be lean. FTO variants increase the risk of developing obesity by 20-30 percent. They also have a higher risk of insulin resistance. In addition, carriers of the FTO gene have lower levels of HDL “good” cholesterol. The FTO gene is also linked to childhood obesity.
Another gene, the MC4R, is associated with total energy intake. People with MC4R mutations are more likely to gain weight. It is also associated with higher blood sugar levels, which could lead to diabetes. MC4R mutations are common causes of severe childhood-onset obesity.
Researchers also found that the MC4R gene is associated with a higher BMI. In addition, it is also associated with increased energy intake.
Another gene, the APOA2, has a GG variant, which can lead to weight gain on a high-saturated fat diet. This gene produces a protein that affects a person’s response to saturated fat.
